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Anti-XAF1 Antibody

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Specifications Related Products Product Reviews FAQs
Catalog No. Description Amount Price Shipping
TA306145
  • Rabbit Polyclonal XAF-1 Antibody
100ug 3630.00 17-28工作日 Add to Shopping Cart
   TrueMABTM Antibodies
* Delivery is in business days
WB(1)
IHC(1)
IF(1)
Also for XAF1 (Locus ID 54739)
Gene NameHomo sapiens XIAP associated factor 1 (XAF1), transcript variant 1 Synonyms:BIRC4BP; HSXIAPAF1; XIAPAF1
ImmunogenXAF-1 antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human XAF-1.
BufferPBS containing 0.02% sodium azide.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Purification Affinity chromatography purified via peptide column
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 0.5 - 2 ug/mL, ICC: 2 ug/mL, IF: 10 ug/mL
BackgroundXAF-1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus (1,2). Overexpression of XAF-1 results in the neutralization of XIAP's ability to inhibit cell death (1). XAF-1 is normally expressed in all adult and fetal tissues but was found to be present in very low levels in a variety of cancer cell lines (3). In contrast, XIAP levels have been shown to be high in a majority of cell lines. Low XAF-1 and high basal expression of XIAP may therefore play a critical role in maintaining survival of cancer cell lines (2,3). Both IFN-alpha2 and IFN-beta can induce XAF-1 mRNA in all cells examined but induction of XAF-1 protein (as observed by immunoblot analysis) was seen only in cell lines sensitive to the apoptotic effects of IFNs (4).
Related Pathway

* OriGene provides validated application data and protocol, with money back guarantee.


WB Image
Western blot analysis of XAF-1 in human spleen lysate with XAF-1 antibody at 0.5 (lane A), 1 (lane B), and 2 (lane C) ug/ml, respectively.
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IHC Image
Immunohistochemical staining of human spleen tissue using XAF-1 antibody at 2 ug/ml.
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IF Image
Immunofluorescence of XAF-1 in Human Spleen tissue with XAF-1 antibody at 10 ug/mL.
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