Neuropeptide Y / NPY Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC
Recommend Dilution	IHC Quality Control:  In rat central nervous system, the antiserum has significant staining with a very low background at a 1/5,000 –1/10,000 dilution using the Biotin-Streptavidin/HRP detection method. All staining is blocked by preabsorption of the diluted antiserum with excess NPY. Cross reactivity experiments in which diluted NPY antiserum was absorbed with excess peptide YY, avian pancreatic polypeptide, B-endorphin, vasoactive intestinal peptide, cholecystokinin or somatostatin showed no affect in blocking the intensity of staining.
Reactivity	Amphibian, Birds, Fish, Mammalian
Host	Rabbit
Clonality	Polyclonal
Immunogen	Neuropeptide Y coupled to bovine thyroglobulin (BTg) with glutaraldehyde
Formulation	State: Serum State: Lyophilized whole serum (100 μL) Preservative: ≤ 0.09% sodium azide
Conjugation	Unconjugated
Background	Neuropeptide Y (NPY) is a member of a regulatory peptide family and has marked sequence homology with pancreatic polypeptide (PP) and peptide YY (PYY), which are other members of the family. In the rat central nervous system, immunohistochemistry has found NPY-like cell bodies in the cortex, caudate-putamen, hypothalamus (arcuate nucleus), hippocampus, anterior olfactory bulb, nucleus accumbens, amygdaloid complex and periaqueductal grey. NPY-like fibers and terminals are detected in high numbers in the bed nucleus of the stria terminalis, the peri- and paraventricular regions of the hypothalamus and thalamus and in discrete hypothalamic nuclei, particularly the suprachiasmatic nucleus.
Reference Data

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