Epstein Barr Virus / EBV LMP2A Rat Monoclonal Antibody [Clone ID: 15F9]

Specifications

Product Data
Clone Name	15F9
Applications	IHC, WB
Recommend Dilution	Western Blot: 1/100-1/1000. Immunohistochemistry on Paraffin Sections: This product requires antigen retrieval using heat treatment methods prior to staining of paraffin sections. Sodium citrate buffer pH6.0 is recommended for this purpose.
Reactivity	Epstein Barr Virus
Host	Rat
Clonality	Monoclonal
Immunogen	Bacterial TrpE-LMP2A fusion protein.
Specificity	This antibody recognizes latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV) and does not cross react with LMP2B.
Formulation	PBS, pH 7.4 containing 0.09% Sodium Azide as preservative State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	EBV is a human herpesvirus, which is associated with conditions such as Hodgkins disease and Burkitts Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.
Synonyms	HHV4, HHV-4
Reference Data

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