CD79A (202-216) Mouse Monoclonal Antibody [Clone ID: HM57]

Specifications

Product Data
Clone Name	HM57
Applications	FC
Recommend Dilution	Flow Cytometry analysis of human blood cells: 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
Reactivity	Bovine, Chicken, Equine, Guinea Pig, Human, Mouse, Opossum, Porcine, Rabbit, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide corresponding to 202-216 amino acid sequence of Human mb-1.
Specificity	This antibody interacts with CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.
Formulation	PBS Label: FITC State: Liquid purified IgG fraction Stabilizer: 0.2% (w/v) BSA (high-grade protease free) Preservative: 15 mM sodium azide Label: Conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use.
Conjugation	FITC
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	CD79a molecule
Database Link	Entrez Gene 973 Human UniProt ID P11912
Background	CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.
Synonyms	IGA, MB1, B-Cell marker
Reference Data

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