Sponge Hsp70 Mouse Monoclonal Antibody [Clone ID: IVF5]

CAT#: AM02038PU-N

Sponge Hsp70 mouse monoclonal antibody, clone IVF5, Purified



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CNY 7,447.00


货期*
5周

规格
    • 100 ug

Cited in 2 publications.

Product images

Specifications

Product Data
Clone Name IVF5
Applications ELISA, IHC, IP, WB
Recommend Dilution ELISA: 1/5,000.
Western blot: 1/500.
Immunoprecipitation: 1/50.
Immunohistochemistry: 1/50.
Reactivity Geodia cydonium
Host Mouse
Clonality Monoclonal
Immunogen HSP70 from Geodia cydonium.
Specificity This antibody detects HSP70.
Formulation 50mM TRIS pH 7.4
State: Purified
State: Lyophilized IgG fraction
Reconstitution Method Restore in aqua bidest to 1 mg/ml.
Purification Protein G chromatography
Conjugation Unconjugated
Storage Condition Store lyophilized at 2-8°C and reconstituted at -20°C.
Avoid repeated freezing and thawing.
Background Heat shock proteins (HSPs) or stress response proteins (SRPs) are synthesized in variety of environmental and pathophysiological stressful conditions. Many HSPs are involved in processes such as protein denaturation-renaturation, folding-unfolding, transport-translocation, activation-inactivation, and secretion. HSP70 is found to be associated with steroid receptors, actin, p53, polyoma T antigen, nucleotides, and other unknown proteins. Also, HSP70 has been shown to be involved in protective roles against thermal stress, cytotoxic drugs, and other damaging conditions.

Heat shock proteins are produced by prokaryotic and eukaryotic cells, and are among the most conserved molecules in phylogeny. Eukaryotic cells contain an HSP70 multigene that differ in their intracellular location and regulation. Members of the HSP70 family play a major role in the folding, unfolding and translocation of polypeptides as well as in the assembly and disassembly of oligomeric protein complexes, as well as in the immune response. HSP72 was found to increase dramatically in the brains of Alzheimer’s disease patients, and was localized exclusively in neuritic plaques and neurofibrillary tangles. HSP70 concentrates in nuclei during heat shock and returns to the cytoplasm when the shock is removed.
Synonyms Heat Shock Protein 70
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (2)

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