TAC1 Mouse Monoclonal Antibody [Clone ID: SP-DE4-21]

Specifications

Product Data
Clone Name	SP-DE4-21
Applications	ELISA, IF, IHC
Recommend Dilution	ELISA: 1/10,000. Immunohistochemistry on Vibratome Sections: 1/500-1/1,000. Immunohistochemistry on Frozen Sections: 1/300 (Ref.2-4). Specimen fixation not in Methanol.
Reactivity	Guinea Pig, Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic Human Substance P.
Specificity	The antibody reacts specifically with Substance P. No cross reaction against related Tachykinins (Neurokinin A, Neurokinin B, and Kassinin).
Formulation	0.1M Glycin PBS, pH 7.4 State: Purified State: Lyophilized purified IgG fraction from Cell Culture Supernatant
Reconstitution Method	Restore in aqua bidest to 1 mg/ml.
Concentration	1.0 mg/ml (after reconstitution)
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month  or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	tachykinin precursor 1
Database Link	Entrez Gene 21333 MouseEntrez Gene 24806 RatEntrez Gene 6863 Human UniProt ID P20366
Background	Substance P (SP) is currently thought to be one of the most important neurotransmitters and neurotransmitters in the brain. It is an undecapeptide belonging to the tachykinin family, which consists of excitatory neuropeptides synthesised in neuronal and glial cells of the human central and peripheral nervous system. Substance P, Neurokinin A, Neuropeptide K, and Neuropeptide gamma are all generated by post-translation cleavage of the precursor Protachykinin-1. Substance P forms the major endogenous ligand for Neurokinin 1 Receptor. The pharmacology of Substance P has been associated with a number of neurological and psychiatric disorders, namely nociception, migraine, asthma, nausea, inflammatory bowel syndrome, urinary incontinence, anxiety and depression. It has also been linked to obesity.
Synonyms	Substance-P
Note	LocusID 6863 (tachykinin precursor contains: substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma).
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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