LEF1 (alternate exon) Mouse Monoclonal Antibody [Clone ID: 1C3]

Specifications

Product Data
Clone Name	1C3
Applications	WB
Recommend Dilution	Western Blot: Detect LEF-1 protein containing the alternately spliced exon between amino acids 212-241 at 1-5 µg/ml. Positive Control: Cos cells transfected with LEF-1 protein.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant full-length LEF-1 protein.
Specificity	This antibody recognizes an epitope in amino acids 227-231 of LEF-1. This sequence lies within the context dependent activation domain of LEF-1 and appears to be an alternate splice variant exon of the LEF-1 gene.
Formulation	PBS containing 0.08% Sodium Azide as preservative. State: Purified State: Liquid (sterile filtered) purified IgG fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	lymphoid enhancer binding factor 1
Database Link	Entrez Gene 51176 Human UniProt ID Q9UJU2
Background	Lymphoid Enhancer Factor-1 (LEF-1) is an HMG 1/2-like DNA binding/bending protein and is a member of the LEF/TCF transcription factor family. There are four LEF/TCF family members in mammalian systems (LEF-1, TCF-1, TCF-3 and TCF-4), and orthologs to these factors have been identified in many different species. LEF/TCFs are downstream mediators of Wnt/Wingless signals. Wnt signaling drives cell polarity, cell fate and cell growth decisions in embryonic tissues and in post-natal tissues that continue to develop from mitotically active stem cell precursors. Misregulation of Wnt signaling is also implicated as a root cause of many different cancers, such as colon cancer, melanoma, breast cancer, prostate cancer and others.
Synonyms	Lymphoid enhancer-binding factor 1, LEF-1, T cell-specific transcription factor 1-alpha, TCF1-alpha
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.