TIMP2 Mouse Monoclonal Antibody [Clone ID: 3A4]

Specifications

Product Data
Clone Name	3A4
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western Blot: 1 - 2 µg/ml. Immunohistochemistry on Paraffin Sections: 5-10 µg/ml. Positive Control: Colon and gastric tissues. Stronger expressions observed in tumor versus normal proteins.
Reactivity	Chicken, Human, Mouse, Porcine, Rabbit, Zebrafish
Host	Mouse
Clonality	Monoclonal
Immunogen	Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the Human TIMP-2 protein and mouse myeloma Ag8563 cells.
Specificity	This antibody recognizes Matrix Metalloproteinase 2 (TIMP2).
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.08% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A/G
Conjugation	Unconjugated
Storage Condition	Upon receipt, store (in aliquots) at -20°C to -80°C. Avoid repeated freezing and thawing.
Predicted Protein Size	18.5-21 kDa
Gene Name	TIMP metallopeptidase inhibitor 2
Database Link	Entrez Gene 7077 Human UniProt ID P16035
Background	TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases-1, -2, -3 and -4) complex with metalloproteinases such as collagenases,gelatinases and stromelysins, resulting in irreversible inactivation of the metalloproteinase. TIMP-1 was found to be identical to EPA (erythroidpotentiation activity). Parathyroid hormone has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation,branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart and low levels of TIMP-4 are expressed in liver, brain, lung, thymus and spleen.
Synonyms	CSC-21K, TIMP-2
Reference Data

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