ACTH (POMC) (1-24) Mouse Monoclonal Antibody [Clone ID: 57 (BGN/1388/66)]

Specifications

Product Data
Clone Name	57 (BGN/1388/66)
Applications	ELISA, IHC
Recommend Dilution	ELISA. Immunohistochemistry on Formalin Fixed Paraffin Embedded Sections: 1/100-1/200 (Requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase).
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide corresponding to the amino acids 1-24 of the Human ACTH conjugated to Keyhole Limpet Haemocyanin.
Specificity	This ACTH antibody (Clone 57, BGN/1388/66) recognises 1-24 ACTH (Synacthen) which, as a synthetic analogue of naturally-occurring Adrenocorticotropic Hormone, can be used to measure adrenal reserve and for the diagnosis of adrenal insufficiency by acute adrenocortical stimulation. It does not recognise 17-39 ACTH (CLIP).
Formulation	PBS, pH 7.2 State: Aff - Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	proopiomelanocortin
Database Link	Entrez Gene 5443 Human UniProt ID P01189
Background	ACTH, released from the anterior pituitary gland in response to corticotropin-releasing hormone from the hypothalamus, acts on the adrenal cortex to stimulate the production of corticosteroids such as cortisol, involved in the response to stress. Studies have shown that the administration of 1-24 ACTH increases blood pressure, believed to be attributed to an increase in ACTH-stimulated cortisol secretion, in association with increased cardiac output.
Synonyms	Corticotropin, Adrenocorticotropic hormone, POMC
Reference Data

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