IL6 Mouse Monoclonal Antibody [Clone ID: 6D9A1,6C12B1]

Specifications

Product Data
Clone Name	6D9A1,6C12B1
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/10000. Immunohistochemistry on Paraffin Sections: 1/200. Western Blot: 1/200 - 1/1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Ni-NTA purified recombinant Human IL-6 expressed in E. Coli strain BL21 (DE3)
Specificity	This antibody detects Interleukin 6 (IL6) (Family: Hormone, Subfamily: not assigned-Hormone).
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide as preservative
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	interleukin 6
Database Link	Entrez Gene 3569 Human UniProt ID P05231
Background	Interleukin 6 (IL6) is a multifunctional 24 kDa protein originally discovered in the medium of RNA stimulated fibroblastoid cells. It is upregulated by IL1, TNF, PDGF, IFN beta, TNF alpha, NGF, IL17 and downregulated by glucocorticoids IL4, TGF beta. IL6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be as important as IL1 and TNF alpha in regulating the acute phase response. IL6 has also been implicated in regulating adipose mass. IL6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. It acts upon a variety of cells including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. In addition, IL6 appears to interact with IL2 in the proliferation of T lymphocytes. IL6 potentiates the proliferative effect of IL3 on multipotential hematopoietic progenitors.
Synonyms	IL-6, Interferon beta-2, IFNB2, B-cell stimulatory factor 2, BSF-2, CDF
Reference Data

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