Inhibin alpha (INHA) Mouse Monoclonal Antibody [Clone ID: 4A2]

Specifications

Product Data
Clone Name	4A2
Applications	IF, IHC
Recommend Dilution	ELISA: 1/10000.  Immunofluorescence: 1/200 - 1/1000. Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human INHA expressed in E. Coli.
Specificity	Recognizes INHA (A-Inhibin subunit precursor, inhibin alpha subunit ).
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.03% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	inhibin alpha subunit
Database Link	Entrez Gene 3623 Human UniProt ID P05111
Background	INHA (A-inhibin subunit precursor, inhibin alpha subunit ), also called inhibin (alpha), which is located on chromosome 2q33-q36. Inhibin is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises of two subunits,Inhibin A and B. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa cell tumors and can therefore be used as a marker for primary as well as recurrent disease. In addition to their role in endocrine feedback in the reproductive sytem, inhibins subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal,bone marrow, placenta, and most notably anterior pituitary. Inhibin alpha subunit gene expression is down regulated in human prostate cancer, suggesting a tumor suppressive role.
Synonyms	INHA
Reference Data

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