Cd28 Hamster Monoclonal Antibody [Clone ID: 37.51]

Specifications

Product Data
Clone Name	37.51
Applications	FC, FN, IP
Recommend Dilution	Flow Cytometry (Ref.1,2). Immunoprecipitation (Ref.1). Functional Assay: In vitro costimulation of T cells and NK cells (Ref.1-3,7-9,11).
Reactivity	Mouse
Host	Hamster
Clonality	Monoclonal
Immunogen	C57BL/6N mouse T cell lymphoma EL-4 cell line.
Specificity	This antibody is specific to CD28 costimulatory receptor (Mr. 40 kDa)
Formulation	Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	CD28 antigen
Database Link	Entrez Gene 12487 Mouse UniProt ID P31041
Background	CD28 is a type I disulfide-linked homodimer that is constitutively expressed on most thymocytes, at low density on nearly all CD4+ and CD8+ peripheral T lymphocytes, and at very low levels on NK cells. Its expression is upregulated upon T-cell activation. (Ref.1-4) CD28 is a ligand for CD80/B7-1 and CD86/B7-2 on B cells and other antigen presenting cells, and plays an important role in the interaction between T cells and B cells. CD28 is a co-stimulatory receptor involved in many, but not all, T-cell independent immune responses. (Ref.5-8)
Synonyms	TP44
Reference Data

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