TLR6 Mouse Monoclonal Antibody [Clone ID: 3B6]

Specifications

Product Data
Clone Name	3B6
Applications	ELISA, FC
Recommend Dilution	ELISA: 1/3000-1/5000. Flow Cytometry: 1 µg/106.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody is specific for Toll-like Receptor 6 (TLR6).
Formulation	100 mM Borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	toll like receptor 6
Database Link	Entrez Gene 10333 Human UniProt ID Q9Y2C9
Background	The Toll-like receptor (TLR) family is comprised of Type I transmembrane proteins characterized by an extracellular leucine-rich domain and a cytoplasmic tail that contains a conserved region call the Toll/IL-1 (TIR) domain. First discovered in Drosophila, TLRs recognize specific molecular patterns that are present in microbial components and respond to these components in order eliminate or limit invading microbes. To date, ten mammalian homologs of TLRs have been described. TLRs signal through adaptor molecules such as MyD88 leading to NF-kB activation, c-Jun N-terminal kinase activation (JNK), cytokine secretion and the inflammatory response. The amino acid sequence of human TLR6 is most similar to hTLR1 with 69% identity. TLR6 recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B. burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (Ref.1-6)
Synonyms	Toll-like receptor 6
Reference Data

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