Amyloid Precursor Protein (APP) Mouse Monoclonal Antibody [Clone ID: J4H9]

CAT#: AM09000PU-N

Amyloid Precursor Protein (APP) mouse monoclonal antibody, clone J4H9, Purified

Size: 50 ul 100 ul



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CNY 6,620.00


货期*
5周

规格
    • 100 ul

Cited in 2 publications.

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Specifications

Product Data
Clone Name J4H9
Applications ELISA, IHC, WB
Recommend Dilution ELISA.
Western blot (1/1,000-1/2,000).
Immunohistochemistry on Paraffin Sections (2.5 µg/ml).
This APP antibody was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Immunogen Recombinant Human APP (18-289aa) purified from E. coli
Specificity The antibody recognizes APP.
Formulation PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol
State: Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Protein G Affinity Chromatography
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name amyloid beta precursor protein
Background Amyloid precursor protein (APP) is the precursor molecule whose proteolysis generates amyloid beta (Aβ), a 39- to 42- amino acid peptide and this amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer’s diseases patients. APP is an integral membrane protein that is phosphorylated in the cytoplasmic and extracellular domains. It has been reported that cell-surface APP plays a role in neurite extension of primary cultured hippocampal neurons. The large extracellular domain of APP is also reported to bind extracellular matrix molecules such as heparin, laminin, and collagen, which can mediate cell adhesion and neurite outgrowth. Abnormal regulation of the metabolism of APP may contribute to the deposition of plaques.
Synonyms Alzheimer disease amyloid protein, Amyloid Precursor Protein, ABPP, APPI, PreA4, Cerebral vascular amyloid peptide, CVAP
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (2)

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