FLIP (CFLAR) (1-376) Mouse Monoclonal Antibody [Clone ID: AT8B12]

Specifications

Product Data
Clone Name	AT8B12
Applications	ELISA, IF, WB
Recommend Dilution	ELISA. Western Blot: 1/500-1/1000. Immunofluorescence.
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human FLIP (aa 1-376) purified from E. coli.
Specificity	The antibody recognizes FLIP.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	CASP8 and FADD like apoptosis regulator
Database Link	Entrez Gene 12633 MouseEntrez Gene 117279 RatEntrez Gene 8837 Human UniProt ID O15519
Background	FLIP, also known as CASP8 and FADD-like apoptosis regulator (CFLAR), contains two death effector domains (DEDs) and a caspase-like domain. FLIP may play a crucial role between cell survival and cell death pathway in mammalian cells and interacts with adapter protein FADD and Caspase-8 and -10, and potently inhibits apoptosis induced by all known death receptors DR3 (Death Receptor 3), TRAIL-R (TNF-related apoptosis-inducing ligand receptor) and TNFR1 (Tumor Necrosis Factor Receptor 1).
Synonyms	c-FLIP, CLARP, MRIT, CASH, FLAME-1, CASP8AP1, Usurpin
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Apoptosis

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