BRCC36 (BRCC3) Mouse Monoclonal Antibody [Clone ID: AT3B1]

Specifications

Product Data
Clone Name	AT3B1
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western blot (1:1,000 - 1:2,000). Immunohistochemistry on Paraffin Sections: (5 µg/ml).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant BRCC36 (1-316 aa) purified from E. coli
Specificity	The antibody recognizes human BRCC3 / BRCC36. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	BRCA1/BRCA2-containing complex subunit 3
Database Link	Entrez Gene 79184 Human UniProt ID P46736
Background	BRCC3 (BRCC36, BRCA1/BRCA2-containing complex, subunit 36) is a holoenzyme complex containing BRCA1, BRCA2. BRCC36 is an ubiquitin E3 ligase complex that has a role in DNA repair and enhances cellular survival following DNA damage. This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint.
Synonyms	BRCC36, C6.1A, CXorf53
Reference Data
Protein Families	Druggable Genome, Protease

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