PDK1 (29-436) Mouse Monoclonal Antibody [Clone ID: AT2D6]

Specifications

Product Data
Clone Name	AT2D6
Applications	ELISA, FC, IF, WB
Recommend Dilution	ELISA. Western blot (1:250 - 1:1,000). Immunocytochemistry / Immunoflourescence. Flow cytometry.
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human PDK1 (29-436 aa) purified from E. coli
Specificity	The antibody recognizes PDK1 at aa 29-436.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	pyruvate dehydrogenase kinase 1
Database Link	Entrez Gene 116551 RatEntrez Gene 5163 Human UniProt ID Q15118
Background	PDK1 (pyruvate dehydrogenase kinase isoform 1) is involved in the regulation of enzymatic activity of mammalian pyruvate dehydrogenase (PDH) that is a part of a mitochondrial multienzyme complex to catalyze the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. PDK1 has been found to serve as an effective therapeutic target for inhibition of glioblastoma growth.
Synonyms	Pyruvate dehydrogenase kinase isoform 1
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Fc epsilon RI signaling pathway, Neurotrophin signaling pathway, T cell receptor signaling pathway

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