beta 2 Microglobulin (B2M) Mouse Monoclonal Antibody [Clone ID: D3A2]

Specifications

Product Data
Clone Name	D3A2
Applications	ELISA, FC, IF, WB
Recommend Dilution	ELISA: 1 µg/ml coated antigen can be detected by ≥ 1ng/ml of antibody.  The antibody can detect Human B2MG in Sandwich ELISA in combination with capture antibody, anti-B2MG mAb D2E9.  Western Blot: 1 µg/ml. Immunofluorescence: 1/50 (20 µg/ml).  Fluorescence Flow Cytometry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Highly purified recombinant Beta-2-Microglobulin from Human Urine.
Specificity	This monoclonal antibody reacts with natural and recombinant Human Beta-2 MG.
Formulation	0.01M PBS, pH 7.2 without preservatives. State: Aff - Purified State: Lyophilized purified IgG fraction.
Reconstitution Method	Restore with Double distillated water to a final concentration to 1.0 mg/ml.
Purification	Affinity Chromatography on Protein G.
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month  or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	beta-2-microglobulin
Database Link	Entrez Gene 567 Human UniProt ID P61769
Background	Human beta 2 microglobulin (B2MG) is a component of major histocompatibility complex 1 (MHC1).  It is abundant at the surface of lymphocytes and exists at the surface of all cell types except red cells and platelets.  B2MG is normally filtered out of blood through glomeruli, but the process is impaired in patients with renal diseases.  Elevated B2MG level is implicated with lymphoma, multiple myeloma, renal diseases, viral infections and auto-immune conditions.
Synonyms	B2M, Beta-2 microglobulin, Beta 2 microglobulin
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Antigen processing and presentation

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