SHP1 (PTPN6) Mouse Monoclonal Antibody [Clone ID: PTY11]

CAT#: AM09319PU-N

SHP1 (PTPN6) mouse monoclonal antibody, clone PTY11, Purified



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CNY 7,733.00


货期*
4周

规格
    • 500 ug

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Specifications

Product Data
Clone Name PTY11
Applications ELISA, IF, IHC, WB
Recommend Dilution ELISA.
Western Blot.
Immunocytochemistry.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Purified recombinant protein corresponding to full-length PTP1-C
Specificity This antibody recognizes single 67kDa PTP1-C in Human cells that express the enzyme and the SH2(C) domain.
Formulation 0.01M PBS, pH 7.2 without preservatives
State: Purified
State: Lyophilized purified IgG fraction
Reconstitution Method Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml.
Purification Affinity chromatography on Protein G
Conjugation Unconjugated
Storage Condition Upon receipt, store (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Gene Name protein tyrosine phosphatase, non-receptor type 6
Background The phosphorylation state of receptors and signal transduction molecules influences almost every cell activities. The phosphorylation rate is regulated by kinases which add phosphate group and by phosphatases which remove phosphate group form the amino acid residues on protein molecules. Protein tyrosine phosphatase 1 C (PTP1C) is a tyrosine phosphatase highly expressed in heomatopoietic cells. PTP1C was found to co-precipitate with B lymphocytespecific cell surface glycoprotein CD22, after anti-immunoglobulin stimulation. Study with PTP1C deficient mice showed that the phosphatase may implicate with negative selection in B cell immunity.
Synonyms PTPN-6, HCP, PTP1C, Protein-tyrosine phosphatase 1C, PTP-1C, SH-PTP1, Protein-tyrosine phosphatase SHP-1
Reference Data
Protein Families Druggable Genome, Phosphatase, Stem cell - Pluripotency
Protein Pathways Adherens junction, B cell receptor signaling pathway, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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