Thymidylate Synthase (TYMS) Mouse Monoclonal Antibody [Clone ID: AT1S5]

CAT#: AM09355PU-S

Thymidylate Synthase (TYMS) mouse monoclonal antibody, clone AT1S5, Purified

Size: 50 ul 100 ul



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CNY 5,630.00


货期*
5周

规格
    • 50 ul

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Specifications

Product Data
Clone Name AT1S5
Applications ELISA, IF, WB
Recommend Dilution ELISA.
Western blot (1:500 - 1:1,000).
Immunofluorescence (1:500 - 1:1,000).
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Recombinant TYMS (1-313 aa) purified from E. coli
Specificity The antibody recognizes human TYMS. Other species not tested.
Formulation PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol
State: Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Protein-G affinity chromatography
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name thymidylate synthetase
Background The methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dMTP) is an essential step for the formation of thymine nucleotides. This process is catalyzed by thymidylate synthase (TS or TYMS). TYMS is an intracellular enzyme that provides the sole de novo source of thymidylate in activity highest proliferating cells. Being the exclusive source of dTMP, TS is also an important target for anticancer agents such as 5-fluorouracil (5-FU). 5-FU acts as a TS inhibitor and is active against solid tumors such as colon, breast, head and neck. TS expression may be useful in predicting overall patient survival, but the prognostic value of TS expression continues to be a subject of investigation for different types of cancers.
Synonyms TYMS, TSase, OK/SW-cl.29
Reference Data
Protein Families Druggable Genome
Protein Pathways Metabolic pathways, One carbon pool by folate, Pyrimidine metabolism
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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