Aurora B (AURKB) Mouse Monoclonal Antibody [Clone ID: AT2B1]

Specifications

Product Data
Clone Name	AT2B1
Applications	ELISA, FC, IF, WB
Recommend Dilution	ELISA.  WesternBlot. Flow Cytometry. Immunofluorescence: 1/1000-1/2000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human Aurora kinase B (1-344aa) purified from E. coli
Specificity	The antibody recognizes Human Aurora kinase B. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	aurora kinase B
Database Link	Entrez Gene 9212 Human UniProt ID Q96GD4
Background	The aurora family (A, B and C) are serine threonine kinases and key regulators of chromosome segregation during mitosis. Aurora kinase B is a chromosomal passenger protein that regulates chromosome segregation and cytokinesis. Aurora kinase B is associated with the level of genetic instability within tumours and patient survival. It is strongly expressed in exponentially proliferating bronchial epithelial cells in culture and that this expression is markedly reduced in confluent cells. It is also shown that almost all tumours show higher levels of Aurora kinase B expression than their matched normal lung tissues, which could therefore simply be a consequence of a higher proliferative index, or be typical of the progenitor cell and atypical of the bulk of normal lung cells.
Synonyms	Aurora-B, Aurora/IPL1-related kinase 2, STK-1, AURKB, AIK2, AIM1, ARK2, STK12
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Stem cell - Pluripotency

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