KDEL Receptor (KDELR1) (C-term) Mouse Monoclonal Antibody [Clone ID: 2E7]

CAT#: AM20047PU-N

KDEL Receptor (KDELR1) (C-term) mouse monoclonal antibody, clone 2E7, Purified



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CNY 5,962.00


货期*
4周

规格
    • 100 ug

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Specifications

Product Data
Clone Name 2E7
Applications IF, WB
Recommend Dilution Western blot: 1/1000-1/2000.
1 µg/ml of this antibody was sufficient for detection of HDEL-containing proteins in 10 µg of S. cerevisiae lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG -HRP as the secondary antibody.
Immunofluorescence: 1/50-1/500.
Reactivity Drosophila, Plant, Yeast
Host Mouse
Clonality Monoclonal
Immunogen A synthetic HDEL peptide corresponding to the C-terminus of Yeast Bip.
Specificity Detects ~78kDa protein.
The 2E7 clone recognizes the C-terminal peptide HDEL, a common version of the endoplasmic reticulum retention signal found in Yeast, Plant, nematode and other ER proteins. It specifically stains HDEL proteins in barnyard grass, beet, cotton, mung bean, sorghum and wheat (4).
Formulation PBS, pH 7.4 containing 50% Glycerol with 0.09% Sodium Azide as preservative
State: Purified
State: Liquid purified IgG fraction
Concentration lot specific
Purification Protein G Chromatography
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name KDEL endoplasmic reticulum protein retention receptor 1
Background HSP 70 family comprises four highly conserved proteins, HSP 70, HSC 70, GRP 75 and GRP 78, which serve a variety of roles. They act as molecular chaperones, facilitating the assembly of multi-protein complexes; participate in the translocation of polypeptides across cell membranes and to the nucleus; and aid in the proper folding of nascent polypeptide chains (1, 2). GRP 78 is localized in the endoplasmic reticulum (ER), where it receives imported secretory proteins and is involved in the folding and translocation of nascent peptide chains (2). Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually KDEL in animal cells, and HDEL in S.cerevisiae (3).
Synonyms KDEL endoplasmic reticulum protein retention receptor 1, ERD2.1, ER marker
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Vibrio cholerae infection
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