Cathepsin L (CTSL) Mouse Monoclonal Antibody [Clone ID: CP-L14]

Specifications

Product Data
Clone Name	CP-L14
Applications	IHC, WB
Recommend Dilution	Western Blot: 2 μg/ml. Immunohistochemistry on frozen sections, formalin/aceton fixed tissues: 4 μg/ml.
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Procathepsin L isolated from the human lung cancer cell line EPLC 32M1.
Specificity	This antibody reacts to Cathepsin L1.
Formulation	1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative. State: Aff - Purified State: Lyphilized purified Ig fraction
Reconstitution Method	Restore with 1.2% sodium acetate or neutral PBS.
Concentration	0,1 mg/ml (after reconstitution with PBS)
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cathepsin L
Database Link	Entrez Gene 13039 MouseEntrez Gene 25697 RatEntrez Gene 1514 Human UniProt ID P07711
Background	Cathepsin L is a lysosomal cysteine proteinase with a major role in intracellular protein catabolism. It also shows the most potent collagenolytic and elastinolytic activity in vitro of any of the cathepsins.Cathepsin L has been implicated in pathologic processes including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. Human liver cathepsin L consists of a heavy chain of about 25 kD and a light chain of about 5 kD. The gene is mapped to 9q21-q22. Cathepsin L is required for endothelial progenitor cell-induced neovascularization.
Synonyms	CTSL1, CTSL, MEP, Cathepsin-L1
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Antigen processing and presentation, Lysosome

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