Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone ID: 2D4]

Specifications

Product Data
Clone Name	2D4
Applications	ELISA, IF, IHC
Recommend Dilution	Immunoassay. Immunoflourescence. Flow Cytometry (starting working dilution is 1/50). Immunohistochemistry on Frozen Sections (starting working dilution is 1/50). The antibody is not useful for Western blotting, Immunopurification and Immunohistochemistry on Paraffin Embedded Sections.
Reactivity	Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Specificity	This monoclonal antibody 2D4 recognizes Rat Myeloperoxidase (MPO). Cross reacts with Mouse MPO.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered purified Ig fraction Stabilizer: 0.1% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	myeloperoxidase
Database Link	UniProt ID P05164
Background	MPO is a glycoprotein with an alpha2beta2 heteromultimer expressed in all cells of the myeloid linage. MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils. It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defense of the organism through production of hypochlorous acid (HOCl), a potent oxidant. MPO is rapidly released by activated polymorphonuclear neutrophils. Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer, Alzheimer's disease and multiple sclerosis. Autoimmune antibodies to MPO are involved in Wegeners disease. Since the discovery of MPO deficiency, initially regarded as rare and restricted to patients suffering from severe infections, MPO has more attracted clinical attention. In experimental studies antibodies to MPO can be used for various purposes ranging from flow cytometric analysis to detection of polymorphonuclear neutrophils in tissue sections.
Synonyms	MPO
Reference Data

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