Timd4 Hamster Monoclonal Antibody [Clone ID: Kat5-18]

Specifications

Product Data
Clone Name	Kat5-18
Applications	ELISA, FN, IF
Recommend Dilution	Flow cytometry: The typical starting working dilution is 1:50. Functional assays: Blocks the engulfment of apoptotic cells by thymic macrophages. Immunoassays. Immunoflourescence. Does not work in Immunohoistochemistry on frozen and paraffin sections or Western blot.
Reactivity	Mouse
Host	Hamster
Clonality	Monoclonal
Immunogen	Mouse peritoneal cells
Specificity	The monoclonal antibody Kat5-18 recognizes T-cell immunoglobulin and mucin domain containing molecule (TIMD-4, also called TIM-4).
Formulation	PBS State: Purified State: Liquid purified 0.2 µm filtered purified Ig fraction Stabilizer: 0.1% bovine serum albumin
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C.
Gene Name	T cell immunoglobulin and mucin domain containing 4
Database Link	Entrez Gene 276891 Mouse UniProt ID Q6U7R4
Background	TIMD-4 is a type I transmembrane protein belonging to the immunoglobulin superfamily, containing one Ig-like V-type (immunoglobulin-like) domain. TIMD-4 is expressed in Mac1+ cells in spleen, lymph nodes and fetal liver. TIMD-4 binds apoptotic cells by recognizing phosphatidylserine via its immunoglobulin domain. TIMD-4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIMD-4 is involved in regulating T-cell proliferation and lymphotoxin signaling. TIMD-4 and TIMD-1 are phosphatidylserine receptors for the engulfment of apoptotic cells, and are also involved in intracellular signaling in which exosomes are involved.
Synonyms	TIMD-4, TIM4, TIM-4, T-cell membrane protein 4
Reference Data

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