Claudin 6 (CLDN6) Rat Monoclonal Antibody [Clone ID: YD-9H8]

Specifications

Product Data
Clone Name	YD-9H8
Applications	ELISA, FC, WB
Recommend Dilution	Flow cytometry: 1.2 µg/106 cells. ELISA: 1/200-1/400. CELISA: 1/200-1/400. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
Reactivity	Human
Host	Rat
Clonality	Monoclonal
Immunogen	cDNA encoding Human Claudin 9.  Selection: based on recognition of the complete native protein expressed on transfected mammalian cells.
Specificity	This antibody detects Human Claudin-6 and Claudin-9.
Formulation	PBS, pH 7.2 State: Purified State: Liquid purified Ig fraction Preservative: None
Concentration	lot specific
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	claudin 6
Database Link	Entrez Gene 9074 Human UniProt ID P56747
Background	Claudin 6 and Claudin 9 belong to the claudin family which constitutes a large group of four - transmembrane domain proteins (1) . Claudins are integral tight junction proteins that are responsible for maintaining the integrity of epithelial cell architecture, the control of parace llular transport and cell polarity. The expression pattern of claudins is tissue specific, most tissues express multiple claudins, which can interact in both homotypic and heterotypic fashion to form the tight junction strands (2) . Several claudin proteins have been shown to be abnormally expressed in cancers. The differential expression of these proteins between tumour and normal cells, in addition to their membrane localisation, makes them prime candidates for cancer therapy (2). Members of the claudin fa mily, including Claudin 6 and 9 are expressed in the liver and play a critical role in Hepatitis C Infection. They function as coreceptors in HCV entry and assume a role in HCV dissemination, replication and pathogenesis (3).
Synonyms	CLDN6, PRO1488, Skullin, Skullin 2, UNQ757, CLDN9
Reference Data

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