Thrombomodulin (THBD) Mouse Monoclonal Antibody [Clone ID: B-S24]

Specifications

Product Data
Clone Name	B-S24
Applications	ELISA
Recommend Dilution	ELISA.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Eahy 926 cell lines.
Specificity	Recognises Thrombomodulin (TM), a 105 kDa protein.
Formulation	0.22 µm Sterile-filtered PBS.   Carrier and preservative free. State: Azide Free State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Ion Exchange Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to 12 months. For longer storage freeze aliquots.
Gene Name	thrombomodulin
Database Link	Entrez Gene 7056 Human UniProt ID P07204
Background	CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.
Synonyms	Thrombomodulin, THRM, Fetomodulin
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Complement and coagulation cascades

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