CD61 (ITGB3) Mouse Monoclonal Antibody [Clone ID: BB10]

Specifications

Product Data
Clone Name	BB10
Applications	ELISA, IHC, WB
Recommend Dilution	Western blotting: 1/1000.  Immunohistochemical on Frozen Sections.  Other Immunoassays for cellular and tumor biology.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Partially purified platelet glycoprotein IIb/IIIa complex
Specificity	The antibody clone BB10 reacts with beta-3 integrin including the GPIIIa of platelets.
Formulation	PBS State: Ig Fraction State: Liquid Ig fraction Stabilizer: 1.0% BSA Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	integrin subunit beta 3
Database Link	Entrez Gene 3690 Human UniProt ID P05106
Background	CD61 also known as gpIIIa, the common ßsubunit (integrin ß3-chain) of the gpIIb/IIIa complex and the vitronectin receptor (VNR). The gpIIb/IIIa complex and the VNR are integrins, ie, a/b-heterodimeric glycoprotein complexes that are involved in cell adhesion. With the CD41 antigen (gpIIb or aIIb), the CD61 antigen forms the gpIIb/IIIa complex, which acts as a receptor for fibrinogen, von Willebrand factor (vWf), fibronectin and vitronectin on activated platelets. With the CD51 antigen (VNR a-chain or av), the CD61 antigen forms the VNR, which mediates activation-independent cell adhesion to vitronectin, vWf, fibrinogen, and thrombospondin. The CD61 antigen is found on all normal resting and activated platelets. The CD61 antigen is also found on endothelial cells, megakaryocytes, on some myeloid, erythroid and T-lymphoid leukemic cell lines. Beta-3 Integrins contain receptors for vitronectin, fibrinogen, and Von Willebrands factor and, in some instances fibronectin. The aIIb-Integrin subunit is a specific marker for platelets and megakaryocytes and can be utilized for this purpose in various immunological techniques. Monoclonal antibodies against the beta-3 Integrin subunits and the aIIb-Integrin subunit can be used in Immunoblotting, Immunoprecipitation and Immunostaining experiments.
Synonyms	Integrin beta-3, GP3A, GPIIIa
Reference Data

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