Cd8a Mouse Monoclonal Antibody [Clone ID: OX8-2b]

Specifications

Product Data
Clone Name	OX8-2b
Applications	FC, IHC
Recommend Dilution	Flow Cytometric analysis of Rat lymphocytes, especially in multicolor stainings.  Immunohistochemistry on Fresh Frozen Sections.  Immunohistochemistry on Formalin-Fixed Paraffin-Embedded Sections: Citric acid pretreatment is recommended.
Reactivity	Rat
Host	Mouse
Clonality	Monoclonal
Specificity	The antibody binds to a Rat strain-independent epitope of the alpha-chain of CD8, present on the CD8-positive subsets of T cells and NK cells.
Formulation	State: Supernatant State: Hybridoma Culture Supernatant Preservative: 0.05% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for Two months or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	CD8a molecule
Database Link	Entrez Gene 24930 Rat UniProt ID P07725
Background	The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.
Synonyms	CD8 alpha chain, CD8A, MAL
Reference Data

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