EMA (MUC1) Mouse Monoclonal Antibody [Clone ID: 175C5]

Specifications

Product Data
Clone Name	175C5
Applications	ELISA, EM, FC, IF, IHC, IP, WB
Recommend Dilution	ELISA.  Western Blot.  Immunofluorescence.  Immunoprecipitation. Electron Microscopy. Flow Cytometry. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections (10 µg/ml).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human mammary carcinoma cell line (ZR-75-1).
Specificity	Shows a high preference for breast carcinomas relative to normal breast epithelium. The antibdy reacts with a carcinoma-associated antigen in both adenocarcinomas and squamous cellcarcinomas of different origins.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	mucin 1, cell surface associated
Database Link	Entrez Gene 4582 Human UniProt ID P15941
Background	This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. Mucin 1, cell surface associated (MUC-1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans. MUC-1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with colon, breast, ovarian, lung and pancreatic cancers.
Synonyms	MUC-1, PEMT, Episialin, EMA, H23AG, PUM, DF3, CA 15-3
Reference Data

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