FPRL1 (FPR2) (Extracell. Dom) Mouse Monoclonal Antibody [Clone ID: 3D7]

Specifications

Product Data
Clone Name	3D7
Applications	ELISA, WB
Recommend Dilution	ELISA: In indirect ELISA, the antibody is reactive to the peptide (ASWGGTPEERLKC) from the 2nd Extracellular loop of Human FPRL1.  Western Blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A short peptide (ASWGGTPEERLKC) corresponding to the amino acids on the 2nd extracellular loop of Human FPRL1
Specificity	This antibody is reactive to the peptide (ASWGGTPEERLKC) from the 2nd Extracellular loop of Human FPRL1 and is also reactive to intact Human FPRL1.
Formulation	0.01M PBS, pH 7.2 without preservatives State: Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Upon receipt, store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	formyl peptide receptor 2
Database Link	Entrez Gene 2358 Human UniProt ID P25090
Background	FPRL1 is a low affinity receptor to N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). FPRL1 has been reported in phagocytes, monocytes, neutrophils, differentiated myeloid cells from bone marrow, granulocyte HL-60 cells, and synovial fibroblasts. ESTs have been isolated from blood, leukocyte, lung, and placenta libraries.
Synonyms	N-formyl peptide receptor 2, FMLP-R-I, FPRH1, RFP, LXA4R
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction

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