Staphylococcus aureus Enterotoxin B Mouse Monoclonal Antibody [Clone ID: SEB]

Specifications

Product Data
Clone Name	SEB
Applications	ELISA
Recommend Dilution	ELISA. This Staphylococcal Enterotoxin B (Clone SEB) as a superantigen for T-lymphocytes is a potential targeting antigen in cancer immunotherapy. It has been suggested that monoclonal antibody to SEB has been useful in immunotherapy research.
Reactivity	Staphylococcus aureus
Host	Mouse
Clonality	Monoclonal
Immunogen	SEB purified from Staphylococcus aureus.
Specificity	Staphylococcal Enterotoxin B (SEB).
Formulation	0.01M PBS, pH 7.2 without preservatives State: Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml.
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Database Link	UniProt ID P01552
Background	Staphylococcal enterotoxin B (SEB) is an enterotoxin secreted by Staphylococcus aureus. The bacterium thrives on meet, baking and dairy products and also colonizes in host nasal passageway. Ingestion of SEB contaminated food is the common cause of “food poisoning”, manifested by flu-like symptoms, vomiting, diarrhea and intestinal cramps. In severe cases, SEB can cause respiratory failure and systemic toxic shock. These symptoms are the results of increased membrane permeability and abnormal activation of Tlymphocytes by SEB. SEB acts as a superantigen by binding directly to major histocompatibility complex class II (MHCII) on antigen presenting cells, thus, causing massive CD4 and CD8 Tcells activation and cytokine production. If unchecked, the process can result in systemic organ failure and death.
Synonyms	SEB, entB, S. aureus
Reference Data

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