PAI1 (SERPINE1) Mouse Monoclonal Antibody [Clone ID: 1D5]

Specifications

Product Data
Clone Name	1D5
Applications	ELISA, FC, IHC, WB
Recommend Dilution	ELISA: 1/10000.  Western Blot: 1/500-1/2000.  Flow Cytometry: 1/200-1/400.  Immunohistochemistry on Paraffin Sections: 1/200-1/1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Human SERPINE1 expressed in E. Coli.
Specificity	This antibody recognizes Human SERPINE1 / PAI-1. Other species not tested.
Formulation	PBS State: Purified State: Liquid purified Ig fraction Stabilizer: 0.5% BSA Preservative: 0.05% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	45 kDa
Gene Name	serpin family E member 1
Database Link	Entrez Gene 5054 Human UniProt ID P05121
Background	This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms	Serpin E1, PLANH1, Plasminogen Activator Inhibitor 1, PAI-1, PAI
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Complement and coagulation cascades, p53 signaling pathway

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