PD1 (PDCD1) Mouse Monoclonal Antibody [Clone ID: 1C4]

Specifications

Product Data
Clone Name	1C4
Applications	ELISA, WB
Recommend Dilution	Indirect ELISA.  Western Blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	40kDa recombinant Human Programmed Cell Death-1 (PD-1).
Specificity	Reactive with recombinant Human Programmed Cell Death-1 (PD-1). Reactivity with natural PD-1 has not been evaluated.
Formulation	0.01M PBS, pH 7.2 without preservatives State: Aff - Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml.
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month  or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	programmed cell death 1
Database Link	Entrez Gene 5133 Human UniProt ID Q15116
Background	Programmed Cell Death-1 (PD-1), also called CD279, is a 288 amino acid cell surface protein that belongs to the immunoglobulin superfamily. The protein is expressed on T cells, B cells and macrophages.  When PD-1 is joined with its ligand (CD274 or B7-H1), the immune cell’s activation and effector function are attenuated.  Research suggested that PD1 pathway is mainly involved with attenuation at periphery sites while the B7/CTLA-4 pathway is primarily involved with the attenuation of the activation of immune cells in secondary lymphoid organs. PD-1 pathway is implicated with cancer’s immune-evasion, autoimmunity, and Listeria monocytogenes infection.
Synonyms	Protein PD-1, hPD-1, PDCD1
Reference Data

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