PNMT Mouse Monoclonal Antibody [Clone ID: AT1C11]

Specifications

Product Data
Clone Name	AT1C11
Applications	ELISA, IF, WB
Recommend Dilution	ELISA. Western blot (1/500).  Immunofluorescence (1/100).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human PNMT (1-282aa) purified from E. coli
Specificity	The antibody recognizes Human PNMT. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	phenylethanolamine N-methyltransferase
Database Link	Entrez Gene 5409 Human UniProt ID P11086
Background	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the synthesis of epinephrine and plays an important role in regulating cardiovascular function. Expression of PNMT is regulated by hormonal and neural stimuli because its promoter contains sequences responding to cholinergic and depolarization stimuli. PNMT is the final enzyme in the catecholamine pathway, catalyzing the conversion of norepinephrine to epinephrine using as the cosubstrate and methyl donor, S-adenosylmethionine.
Synonyms	PNMTase
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, Tyrosine metabolism

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