CTLA4 (36-161) Mouse Monoclonal Antibody [Clone ID: AT4F2]

Specifications

Product Data
Clone Name	AT4F2
Applications	ELISA, FC, IF, WB
Recommend Dilution	ELISA. Western blot: Recommended starting dilution is 1:3000. Immunocytochemistry / Immunoflourescence. Flow cytometry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human CTLA4 (36-161aa) purified from E. coli
Specificity	This antibody detects CTLA4 at aa 36-161.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cytotoxic T-lymphocyte associated protein 4
Database Link	Entrez Gene 1493 Human UniProt ID P16410
Background	CTLA4 (Cytotoxic T-Lymphocyte Antigen 4), also known as CD152, is a protein receptor that downregulates the immune system. CTLA4 is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Mutations in CTLA4 have been associated with insulin-dependent diabetes mellitus, Graves' disease, Hashimoto's thyroiditis, celiac disease and other autoimmune diseases.
Synonyms	CTLA-4
Reference Data

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