CKMT1B Mouse Monoclonal Antibody [Clone ID: AT17A2]

Specifications

Product Data
Clone Name	AT17A2
Applications	ELISA, FC, IF, WB
Recommend Dilution	ELISA.  Western blot. Flow Cytometry.  Immunofluorescence. Recommended starting dilution is 1:1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human CKMT1A (40-417aa) purified from E. coli
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	creatine kinase, mitochondrial 1B
Database Link	Entrez Gene 548596 HumanEntrez Gene 1159 Human UniProt ID P12532
Background	CKMT1A, also known as Creatine kinase, mitochondrial 1A, is 417 amino acid protein. Mitochondrial creatine kinase (MtCK) exists as two isoenzymes, sarcomeric MtCK (CKMT2) and ubiquitous MtCK (CKMT1). It is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis.
Synonyms	CKMT1A, CKMT1B, U-MtCK, Mia-CK, Creatine kinase U
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Arginine and proline metabolism, Metabolic pathways

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