CD64 (FCGR1A) Mouse Monoclonal Antibody [Clone ID: AT37F7]

Specifications

Product Data
Clone Name	AT37F7
Applications	ELISA, WB
Recommend Dilution	The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:2000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human FCGR1A (16-292aa) purified from E.coli.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	Fc fragment of IgG receptor Ia
Database Link	Entrez Gene 2209 Human UniProt ID P12314
Background	High affinity immunoglobulin gamma Fc receptor I (FCGR1A) is a protein that in humans is encoded by the FCGR1A gene. Also, This protein is known as CD64, belongs to the immunoglobulin superfamily. It is a high-affinity Fc-gamma receptor. They are playing a role in both innate and adaptive immune responses. They have been shown to interact with FCAR. The FcgRI binds the Fc portion of IgG and causes activation of the host cell via an intercellular ITAM motif.
Synonyms	IgG Fc receptor I, FcgammaRIa, FcRI, Fc-gamma RI, Fc-gamma RIA
Reference Data
Protein Families	Transmembrane
Protein Pathways	Fc gamma R-mediated phagocytosis, Hematopoietic cell lineage, Systemic lupus erythematosus

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