PMVK Mouse Monoclonal Antibody [Clone ID: AT21C10]

Specifications

Product Data
Clone Name	AT21C10
Applications	ELISA, FC, IF, WB
Recommend Dilution	The antibody has been tested by ELISA, Western blot analysis, ICC/IF and Flow cytometry to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human PMVK (1-192aa) purified from E. coli.
Formulation	Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol. State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	phosphomevalonate kinase
Database Link	Entrez Gene 10654 Human UniProt ID Q15126
Background	Phosphomevalote kise, also known as PMVK, is a cytosolic enzyme. It was expressed highly in heart, liver, skeletal muscle, kidney and pancreas and slightly lower in brain, placenta, and lung. Induced by sterol, PMVK participates in isopentenyl diphosphate biosynthesis via the mevalote pathway. PMVK catalyzes the conversion of mevalote 5-phosphate into mevalote 5-diphosphate in the fifth reaction of the cholesterol biosynthetic pathway.
Synonyms	Phosphomevalonate kinase, PMKase, PMKI, HUMPMKI
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, Terpenoid backbone biosynthesis

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