Cyclin H Mouse Monoclonal Antibody [Clone ID: AT3G6]

Specifications

Product Data
Clone Name	AT3G6
Applications	ELISA, WB
Recommend Dilution	The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution for Western blot analysis is 1:1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human Cyclin H (1-323aa) purified from E.coli.
Formulation	Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol. State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cyclin H
Database Link	Entrez Gene 902 Human UniProt ID P51946
Background	The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kises. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordition of each mitotic event. This cyclin forms a complex with CDK7 kise and ring finger protein MAT1. The kise complex is able to phosphorylate CDK2 and CDC2 kises, thus functions as a CDK-activating kise (CAK). This cyclin and its kise partner are components of TFIIH, as well as R polymerase II protein complexes. They participate in two different transcriptiol regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery.
Synonyms	Cyclin-H, MO15-associated protein, p37, p34, CCNH
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Cell cycle, Nucleotide excision repair

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