Alpha-actinin-1 / ACTN1 Mouse Monoclonal Antibody [Clone ID: AT1D10]

Specifications

Product Data
Clone Name	AT1D10
Applications	ELISA, FC, IF, WB
Recommend Dilution	ELISA. Western blot. Flow cytometry. Immunofluorescence.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human ACTN1 (1-249aa) purified from E. coli.
Formulation	Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol. State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	actinin alpha 1
Database Link	Entrez Gene 87 Human UniProt ID P12814
Background	ACTN1 also known as Actinin, alpha 1. ACTN1 functions as an actin-binding-protein. ACTN1 determines the motility of keratinocytes by regulating the organization of the actin cytoskeleton, focal adhesion, and hemidesmosome proteins complexes, thereby modulating cell speed, lamellipodial dymics, and directed migration.
Synonyms	Alpha actinin cytoskeletal isoform, Non-muscle alpha-actinin 1
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS
Protein Pathways	Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Systemic lupus erythematosus, Tight junction

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