PAI1 (SERPINE1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1:50,000. Western blot: 1:5,000. Immunohistochemistry: 1:500.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant human PAI-1
Specificity	This antibody recognizes PAI-1 both alone and in complex under reducing and native conditions.
Formulation	0.05M Sodium phosphate, 0.1M Sodium chloride, 1mM EDTA, pH 6.6 State: Purified State: Liquid purified Ig
Concentration	lot specific
Purification	Protein A chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody at -70°C. Avoid repeated freezing and thawing.
Gene Name	serpin family E member 1
Database Link	Entrez Gene 5054 Human UniProt ID P05121
Background	PAI1 (plasminogen activator inhibitor 1) is originally cloned from human endothelial cell (Pannekoek 1986, Ginsburg 1986) and rat hepatoma cell 3 cDNA libraries. As a member of the serpin family of serine protease inhibitors, PAI1 inhibits both tissue type plasminogen activator (tPA) and urokinase type plasminogen activator (uPA). High PAI1 levels are associated with an increased risk of thromboembolic disease while PAI1 deficiency may represent an inherited autosomal recessive bleeding disorder.
Synonyms	Serpin E1, PLANH1, Plasminogen Activator Inhibitor 1, PAI-1, PAI
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Complement and coagulation cascades, p53 signaling pathway

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