GRK1 Rabbit Polyclonal Antibody

CAT#: AP01451PU-N

GRK1 rabbit polyclonal antibody, Aff - Purified



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CNY 4,640.00


货期*
2周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution Western Blot: 1/500-1/1000.
Immunohistochemistry on paraffin sections: 1/50-1/200.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Specificity GRK1 antibody detects endogenous levels of GRK1 protein. (region surrounding Ala17)
Formulation Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration 1.0 mg/ml
Purification Affinity chromatography
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Predicted Protein Size ~ 63 kDa
Gene Name G protein-coupled receptor kinase 1
Background Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messengerregulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1α and β); two forms of β-adrenergic receptor kinase: GRK 2 (βARK, βARK1) and GRK 3 (βARK2); IT-11 (GRK 4); GRK 5; GRK 6; and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.
Synonyms GRK1, RHOK, G protein-coupled receptor kinase 1
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Chemokine signaling pathway, Endocytosis
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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