MEK3 (MAP2K3) pSer189 Rabbit Polyclonal Antibody

CAT#: AP01635PU-N

MEK3 (MAP2K3) pSer189 rabbit polyclonal antibody, Aff - Purified



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CNY 4,437.00


货期*
2周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications ELISA, IHC, WB
Recommend Dilution ELISA: 1/5000-1/10000.
Western Blot: 1/500-1/1000.
Immunohistochemistry: 1/50-1/200.
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Specificity This antibody detects endogenous levels of MKK3 pSer189 protein.
Formulation Phosphate buffered saline (PBS), pH~7.2 containing 15 mM Sodium Azide as preservative.
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration 1.0 mg/ml
Purification Affinity Chromatography using epitope-specific immunogen.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name mitogen-activated protein kinase kinase 3
Background The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Synonyms MAPKK 3, MEK3, MKK3, MAP kinase kinase 3
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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