Rb (RB1) pSer807 Rabbit Polyclonal Antibody

CAT#: AP01677PU-N

Rb (RB1) pSer807 rabbit polyclonal antibody, Aff - Purified



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CNY 4,437.00


货期*
2周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution Western Blot: 1/500-1/1000.
Immunohistochemistry on paraffin sections: 1/50-1/200.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Specificity This antibody detects endogenous levels of Rb pSer807 protein.
Formulation Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative.
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration 1.0 mg/ml
Purification Affinity Chromatography using epitope-specific immunogen.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Predicted Protein Size ~ 106 kDa
Gene Name RB transcriptional corepressor 1
Background The genetic predisposition to retinoblastoma is transmitted by mutant alleles of the retinoblastoma susceptibility gene (Rb). Rb encodes a phosphorylated protein of approximately 110 kDa that accumulates in the nuclei of most vertebrate cells, but is lacking in all retinoblastomas examined to date. Mutations in Rb have been found in a wide variety of human tumors. The carboxy terminal domain of Rb p110 binds DNA, although no sequence specificity for this binding has been demonstrated. Inactivation of Rb can be mediated by its binding to the transforming proteins of several DNA tumor viruses, including SV40 T antigen and adenovirus E1A, perhaps accounting for their transforming function. Rb p110 is differentially phosphorylated during the cell cycle, implicating a possible role in cell cycle regulation.
Synonyms Retinoblastoma 1, Rb, p105-Rb, pRb, pp110, OSRC
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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