FAK (PTK2) Rabbit Polyclonal Antibody

CAT#: AP02616PU-S

FAK (PTK2) rabbit polyclonal antibody, Aff - Purified

Size: 50 ul 100 ul



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CNY 1,400.00


货期*
2周

规格
    • 50 ul

Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution Western Blot: 1/500~1/1000.
Immunohistochemistry on Paraffin Sections: 1/50~1/100.
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Peptide sequence around aa 859~863 (H-I-Y-Q-P) derived from Human FAK.
Specificity This antibody detects endogenous levels of total FAK protein.
Formulation PBS (without Mg2+ and Ca2+), pH 7.4 containing 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
State: Aff - Purified
State: Liquid purified IgG fraction.
Concentration lot specific
Purification Affinity Chromatography using epitope-specific phosphopeptide.
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name protein tyrosine kinase 2
Background Focal adhesion kinase (FAK) is a non receptor protein tyrosine kinase discovered as a substrate for Src and as a key element of integrin signaling. FAK plays a central role in cell spreading, differentiation, migration, cell death and acceleration of the G1 to S phase transition of the cell cycle. FAK regulation includes phosphorylation at multiple tyrosine and serine residues. Phosphorylation of tyrosine generally is associated with positive regulation and growth promotion, however, dephosphorylation at these sites occurs as cells enter mitosis (M-Phase of the cell cycle). In contrast, serine phosphorylation either remains high or is increased as cells enter mitosis and may play a role in focal adhesion disassembly.
FAK and its phosphorylation states have been implicated in cancer metastasis and tumor cell survival and adhesion-independent growth. Additionally, recent evidence indicates that elevation of FAK activity in human carcinoma cells is associated with increased invasive potential. A central role in tumor formation and progression suggests that FAK is an attractive target for therapeutic intervention.
Synonyms FAK, Focal adhesion kinase 1, FADK1, pp125FAK, Protein-tyrosine kinase 2
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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