SPHK2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	Western Blot: 1:200. ELISA. Positive Control: Active Recombinant Sphingosine Kinase Enzyme.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from the C-terminal of Sphingosine Kinase 2
Specificity	This antibody reacts to SPHK2.
Formulation	Phosphate buffered saline with 0.08% sodium azide State: Aff - Purified State: Liquid purfied Ig
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	The antibody can be shipped on dry ice. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing.
Gene Name	sphingosine kinase 2
Database Link	Entrez Gene 56632 MouseEntrez Gene 308589 RatEntrez Gene 56848 Human UniProt ID Q9NRA0
Background	Sphingosine Kinase 2 (Sphk2) catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors). These receptors couple to multiple G proteins (e.g. S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide range of cellular events including cell motility, survival, apoptosis, migration and cell-cell interaction. Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells. S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).
Synonyms	SK2, SPHK2
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Calcium signaling pathway, Fc gamma R-mediated phagocytosis, Metabolic pathways, Sphingolipid metabolism, VEGF signaling pathway

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