Phosphatidic acid phosphatase type 2B (PLPP3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	Western Blot. Enzyme Immunoassay.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from the phosphatidic acid phosphatase 2B protein
Specificity	This antibody reacts to Phosphatidic Acid Phosphatase 2B .
Formulation	Phosphate buffered saline with 0.08% sodium azide State: Aff - Purified State: Liquid purified IgG
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Ship on dry ice. Store (in aliquots) at -20°C to -70°C. Avoid repeated freezing and thawing.
Gene Name	phospholipid phosphatase 3
Database Link	Entrez Gene 8613 Human UniProt ID O14495
Background	Vascular endothelial growth factor and type I collagen inducible protein (VCIP), also known as phosphatidic acid phosphatase 2b (PAP2b), was originally identified in a functional assay of angiogenesis. VCIP/PAP2b exhibits an Arg - Gly - Asp (RGD) cell adhesion sequence. Immunoprecipitation and fluorescence-activated cell sorting analyses demonstrated that VCIP-RGD is exposed to the outside of the cell surface. Retroviral transduction of VCIP can induce cell aggregation and cell-cell interactions, modestly increase p120 catenin expression and promote activation of the Fak, Akt and GSK3ß protein kinases. Expression of VCIP promoted adhesion, spreading and tyrosine phosphorylation of Fak, Shc, Cas and paxillin in endothelial cells. PAP2b/VCIP is expressed in close proximity to vascular endothelial growth factor, von Willebrand factor and {alpha}vbeta3 integrin in tumor vasculatures.
Synonyms	PAP2-beta, PAP2B, VCIP
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Ether lipid metabolism, Fc gamma R-mediated phagocytosis, Glycerolipid metabolism, Glycerophospholipid metabolism, Metabolic pathways, Sphingolipid metabolism

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