DLL4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	Immunohistochemistry on paraffin sections: 5 - 15µg/ml. ELISA: 1:3000 - 1:15000. Western Blot: 1:300 - 1:1500; detects a band of approximately 74kDa in pancreatic cell lysates.
Reactivity	Human, Monkey, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to the internal region of human DLL4.
Specificity	This antibody detects human Delta-like ligand 4 (DLL4), also known as Delta-4.
Formulation	Phosphate buffered saline pH7.2 containing 0.09% Sodium Azide (NaN3) State: Purified State: Liquid purified IgG
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	delta like canonical Notch ligand 4
Database Link	Entrez Gene 54485 MouseEntrez Gene 311332 RatEntrez Gene 54567 Human UniProt ID Q9NR61
Background	DLL4 is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the Notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumour vessels of clear-cell renal tumours and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumour growth, with no apparent toxicity.
Synonyms	Delta 4, Drosophila Delta homolog 4
Reference Data
Protein Families	Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Transmembrane
Protein Pathways	Notch signaling pathway

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