GJA1 Rabbit Polyclonal Antibody

CAT#: AP06070PU-S

GJA1 rabbit polyclonal antibody, Aff - Purified

Size: 100 ug 25 ul



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CNY 800.00


货期*
2周

规格
    • 25 ul

Product images

Specifications

Product Data
Applications ELISA, IF, IHC, WB
Recommend Dilution Immunofluorescence: 1/50-1/200.
Western blot: 1/500-1/1000.
Immunohistochemistry on Paraffin sections: 1/50-1/200.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide, corresponding to amino acids 340-390 of Human Connexin 43.
Specificity This antibody detects endogenous levels of GJA1 / Cx43 protein (region surrounding Ser369).
Formulation Phosphate buffered saline (PBS), pH 7.2.
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Preservative: 0.05% Sodium azide
Concentration 1.0 mg/ml
Purification Affinity chromatography using epitope-specific immunogen.
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freeze thaw cycles!
Predicted Protein Size ~43 kDa
Gene Name gap junction protein alpha 1
Background Connexin 43 (Cx43) is a member of the large family of gap junction proteins. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels assemble to make gap junctions. Gap junction communication is important in development and regulation of cell growth. Phosphorylation of Cx43 is important in regulating assembly and function of gap junctions. Ser368 of Cx43 is phosphorylated by protein kinase C (PKC) after activation by phorbol esters, which decreases cell-to-cell communication. Src can interact with and phosphorylate Cx43 to alter gap junction communication.
Synonyms Gap junction alpha-1 protein, Connexin-43, GJAL
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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